Spring 2019

January 28

Xie, KT, et al. 2019. DNA fragility in the parallel evolution of pelvic reduction in stickleback fish. Science 363(6422):81-84. doi:10.1126/science.aan1425

February 4 — Polygenic and Complex Traits, Pt 1

Mendes, FK, et al. 2018. A multispecies coalescent model for quantitative traits. eLife 7:e36482 doi:10.7554/eLife.36482



  • Incomplete lineage sorting cannot be ignored when studying quantitative trait evolution on macroevolutionary scales.

  • Moving forward: Estimate levels of ILS from genomic data to help correct for the expected increase in trait variance caused by ILS.

February 25 — Polygenic and Complex Traits, Pt 1

Josephs, EB, et al. 2019. Detecting adaptive differentiation in structured populations with genomic data and common gardens. GENETICS early online. doi:10.1534/genetics.118.301786



  • Detecting adaptation in structured populations requires massive amounts of data and, even then, detection is difficult.

  • Moving forward: In what parameter space are we simply out of luck? When is there too much structure or when is adaptive phenotypic divergence too weak?

Briefly noted

Gupta, K, et al. The Evolution of Placental Invasion and Cancer Metastasis are Causally Linked. BioRxiv doi:10.1101/528646

Alves, JM, et al. 2019. Parallel adaptation of rabbit populations to myxoma virus. Science doi:10.1126/science.aau7285

Glassberg, EC, et al. 2019. Evidence for Weak Selective Constraint on Human Gene Expression. GENETICS 211(2). doi:10.1534/genetics.118.301833

Dung, SK, et al. 2019. Illuminating Women’s Hidden Contribution to Historical Theoretical Population Genetics. GENETICS 211(2). doi:10.1534/genetics.118.301833

Lowry, DB, et al. 2019. Mechanisms of a locally adaptive shift in allocation among growth, reproduction, and herbivore resistance in Mimulus guttatus. Evolution. doi:10.1111/evo.13699

Harkness, A, E Goldberg, Y Brandvain. 2019. The evolutionary response of mating system to heterosis. Journal of Evolutionary Biology. doi:10.1111/jeb.13430

March 4th — The current debate on sweeps, Pt 1

Jensen, JD. 2014. On the unfounded enthusiasm for soft selective sweeps. Nature Communications 5.



  • How might the presence or prevalence of linked deleterious variation affect our expectations for the incidence of soft sweeps?

  • What is the expected pattern of haplotype variation from an incomplete sweep?

Briefly Noted

Buffalo, V, and G Coop. 2019. The Linked Selection Signature of Rapid Adaptation in Temporal Genomic Data. BioRxiv doi:10.1101/559419

Aumer, D, et al. 2019. A Single SNP Turns a Social Honey Bee (Apis mellifera) Worker into a Selfish Parasite. Molecular Biology and Evolution 36(3). doi:10.1093/molbev/msy232.

Paulose, J, J Hermisson, and O Hallatschek. 2019. Spatial soft sweeps: Patterns of adaptation in populations with long-range dispersal. PLoS Genetics doi:10.1371/journal.pgen.1007936

Dixon, JR, et al. 2018. Integrative detection and analysis of structural variation in cancer genomes. Nature Genetics 50:1388–1398

March 11 — The current debate on sweeps, Pt 2

Schrider, DR, and AD Kern. 2017. Soft Sweeps Are the Dominant Mode of Adaptation in the Human Genome. Molecular Biology and Evolution 34(8). 1863–1877. 10.1093/molbev/msx154.

RB Harris, A Sackman, JD Jensen. 2018. On the unfounded enthusiasm for soft selective sweeps II: Examining recent evidence from humans, flies, and viruses. PLoS Genetics. 10.1371/journal.pgen.1007859

Schrider, DR, and AD Kern. 2018. On the well-founded enthusiasm for soft sweeps in humans: a reply to Harris, Sackman, and Jensen. Zenodo. doi:10.5281/zenodo.1473781.